Methylene Blue and Aminoguanidine HCL

Methylthioninium chloride

• Aminoguanidine Hydrochloride — MedChemExpress
• Methylene Blue 1% Solution — Chem-Impex
• Aminoguanidine Hydrochloride — Chem-Impex

[Inflammatory Stimulus] 
       │
       ▼
[iNOS Enzyme]  ◄─── (Inhibited by AMINOGUANIDINE)
       │
       ▼ (Produces)
 [Nitric Oxide (NO)]
       │
       ▼ (Stimulates)
[Soluble Guanylyl Cyclase (sGC)]  ◄─── (Inhibited by METHYLENE BLUE)
       │
       ▼ (Produces)
     [cGMP] ───► [Vasodilation & Hypotension]

NAD+ (NMN, NR)

• Nicotinamide Riboside — MedChemExpress
• Tru Niagen (Nicotinamide Riboside supplement) — ChromaDex

Rapamycin

• Rapamycin (from Streptomyces hygroscopicus) — Chem-Impex

Protocol Outline — adrenochrome (mb, ag) protocol as of 27_JUN_2026

Goal: optimize for mitohormesis, autophagy

Methylene blue (methylthioninium chloride): oxidative pulse, mitohormetic stressor

Aminoguanidine HCL (pimagedine): control quinone reactivity, inhibit AGE's

MRR (Mitohormetic Redox-Relay, mitochondria) - A mechanism where mild oxidative or metabolic stress triggers adaptive, protective responses within mitochondria, enhancing cellular resilience and longevity.